October 2024 Penn Trauma reports examine patient experience, innovations in practice

In October, Penn Trauma faculty published articles reflecting the heterogeneity of trauma care, including the psychopathology of the post-traumatic interim and the role of preoperative CT imaging in penetrating thoracoabdominal injuries.

Featured this month

Dose-Dependent Tranexamic Acid Blunting of Penumbral Leukocyte Mobilization and Blood-Brain Barrier Permeability Following Traumatic Brain Injury: An In Vivo Murine Study.

Culkin MC, Bele P, Georges AP, Santos P, Niziolek G, Kaplan LJ, Smith DH, Pascual JL. Neurocrit Care. 2024 Oct;41(2):469-478. doi: 10.1007/s12028-024-01952-0. Epub 2024 Mar 5. PMID: 38443709

An examination of whether tranexamic acid in early post-traumatic brain injury reduces blood-brain barrier permeability (among other effects) in a dose-dependent manner.

Reward neurocircuitry predicts longitudinal changes in alcohol use following trauma exposure.

Hinojosa CA, van Rooij SJH, Fani N, Ellis RA, Harnett NG, Lebois LAM, Ely TD, Jovanovic T, Murty VP, House SL, Beaudoin FL, An X, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI Jr, Hendry PL, Sheikh S, Jones CW, Punches BE, Hudak LA, Pascual JL, Seamon MJ, Harris E, Pearson C, Peak DA, Merchant RC, Domeier RM, Rathlev NK, O'Neil BJ, Sergot P, Bruce SE, Pizzagalli DA, Sheridan JF, Harte SE, Koenen KC, Kessler RC, McLean SA, Ressler KJ, Stevens JS.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Oct 8:S2451-9022(24)00283-0. doi: 10.1016/j.bpsc.2024.09.015.

Research on the correlates between altered reward-seeking neurocircuitry in the early post-trauma period and vulnerability to trauma-related psychopathologies, including changes in alcohol use.

New Research from Penn Trauma

Role of preoperative CT imaging in penetrating thoraco-abdominal injuries: A multicenter study of urban trauma centers.

American Journal of Surgery. October 2024

Early placement of a non-invasive, pressure-regulated, fascial reapproximation device improves reduction of the fascial gap in open abdomens: a retrospective cohort study.

Trauma Surgery Acute Care Open. October 2024.

Peri-operative strategy in resuscitation of unstable injured surgical patients: a primer.

Postgraduate Medical Journal. October 2024.

The Impact of Palliative Decompressive Gastrostomy Tube Placement on Patients and Their Caregivers: A Mixed Methods Analysis.

Annals of Surgical Oncology. October 2024.

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