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Blood as therapy, pain outcomes, pulmonary mitigations, and ECMO: Penn Trauma reports in December 2024 engage the diverse and evolving terrain of trauma care

January 14, 2025

Topics:

Emergency Medicine and Trauma

As 2024 drew to a close, Penn Trauma reports continued a tradition of insightful explorations of trauma care, deliberations on the efficacy of established therapies, and new and better ways to resolve age-old concerns for affected populations.

Featured this month

  • Red Blood Cells Capture and Deliver Bacterial DNA to Drive Host Responses During Polymicrobial Sepsis.
    Lam LKM, Klingensmith NJ, Sayegh L, Oatman E, Jose JS, Cosgriff CV, Eckart KA, McGinnis J, Ranjan P, Lanza M, Yehya N, Meyer NJ, Dickson RP, Mangalmurti NS.
    J Clin Invest. 2024 Dec 12:e182127. doi: 10.1172/JCI182127.
    A study unveils red blood cells as overlooked reservoirs and couriers of microbial DNA capable of influencing host inflammatory responses in sepsis.
  • Evolution of whole blood trauma resuscitation in childbearing age females: practice patterns and trends.
    Brito AM, Yazer MH, Sperry JL, Luther JF, Wisniewski SR, Guyette F, Moore EE, Cotton BA, Vincent L, Fox E, Cannon JW, Namias N, Minei JP, Ammons LA, Clayton S, Schreiber M.
    Trauma Surg Acute Care Open. 2024 Dec 7;9(1):e001587. doi: 10.1136/tsaco-2024-001587.
    An evaluation of low titer group O whole blood (LTOWB) transfusion in patients with traumatic hemorrhage considers varying practices between institutions regarding transfusion of RhD-positive LTOWB to childbearing age females, a practice concerning for alloimmunization.
  • Tranexamic Acid and Pulmonary Complications: A Secondary Analysis of an EAST Multicenter Trial.
    Raza SS, Tatum D, Nordham KD, Broome JM, Keating J, Maher Z, Goldberg AJ, Chang G, Mendiola Pla M, Haut ER, Tatebe L, Toraih E, Anderson C, Ninokawa S, Maluso P, Burruss S, Reeves M, Coleman LE, Shatz DV, Goldenberg-Sandau A, Bhupathi A, Spalding C, LaRiccia A, Bird E, Noorbakhsh MR, Babowice J, Nelson MC, Jacobson LE, Williams J, Vella M, Dellonte K, Hayward TZ 3rd, Holler E, Lieser MJ, Berne JD, Mederos DR, Askari R, Okafor B, Etchill E, Fang R, Roche SL, Whittenburg L, Bernard AC, Haan JM, Lightwine KL, Norwood SH, Murry J, Gamber MA, Carrick MM, Bugaev N, Tatar A, Duchesne J, Taghavi S.
    Am Surg. 2025 Jan;91(1):107-114. doi: 10.1177/00031348241268109.
    An assessment to determine the capacity of tranexamic acid administration to mitigate pulmonary complications among penetrating trauma patients in the prehospital setting or within three hours of admission.

Also featured in December 2024

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