Laboratory of Molecular Imaging : Research Images about LND

Focus

  • The LMI group employs radiomics in a non-invasive manner to investigate the changing metabolic phenotypes in disease states.
  • The figure portrays the diversity of programs at the LMI, which now encompass research on melanoma, lymphoma, and metabolic modulation in cancer.
  • The LMI group has pioneered the use of advanced MR imaging and spectroscopy protocols, allowing for precise monitoring of dynamic metabolic changes in both disease progression and treatment response.

Faculty And Staff

Adwita Thorat

Student

Aria Eden Osborne

Student

David S Nelson

Research Specialist

Gamaliel Isaac, PhD

Programmer

Meklit Tedla

Student

Mikal Sanaa Banks

Student

Skyler Y Nova

Student

Fernando Arias-Mendoza, MD PhD

Adjunct Associate Professor of Radiology

Pradeep Kumar Gupta, PhD

Research Associate

Mamta Aryabhushan Gupta, PhD

Postdoctoral Researcher 

Dinesh Kumar Singh, PhD

Visiting Scientist

Stepan Orlovskiy

Medical Student

Recent Publications

1. Gupta PK, Orlovskiy S, Arias-Mendoza F, Nelson DS, Nath K. 1H and 31P Magnetic Resonance Spectroscopic Metabolomic Imaging: Assessing Mitogen-Activated Protein Kinase Inhibition in Melanoma. Cells. 2024 Jul 19;13(14):1220. doi: 10.3390/cells13141220. PMID: 39056801; PMCID: PMC11274771.

2. Nath K, Gupta PK, Basappa J, Wang S, Sen N, Lobello C, Tomar JS, Shestov AA, Orlovskiy S, Arias-Mendoza F, Rauert-Wunderlich H, Nelson DS, Glickson JD, Wasik MA. Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition. J Transl Med. 2024 Jul 4;22(1):622. doi: 10.1186/s12967-024-05371-9. PMID: 38965536; PMCID: PMC11225145.

3. Orlovskiy S, Gupta PK, Roman J, Arias-Mendoza F, Nelson DS, Koch CJ, Narayan V, Putt ME, Nath K. Lonidamine Induced Selective Acidification and De-Energization of Prostate Cancer Xenografts: Enhanced Tumor Response to Radiation Therapy. Cancers (Basel). 2024 Mar 31;16(7):1384. doi: 10.3390/cancers16071384. PMID: 38611062; PMCID: PMC11010960.

4. Gupta PK, Orlovskiy S, Arias-Mendoza F, Nelson DS, Osborne A, Pickup S, Glickson JD, Nath K. Metabolic Imaging Biomarkers of Response to Signaling Inhibition Therapy in Melanoma. Cancers (Basel). 2024 Jan 15;16(2):365. doi: 10.3390/cancers16020365. PMID: 38254853; PMCID: PMC10814512

5. Gupta PK, Orlovskiy S, Roman J, Pickup S, Nelson DS, Glickson JD, Nath K. pH-dependent structural characteristics of lonidamine: 1H and 13C NMR study. RSC Adv. 2023 Jul 3;13(29):19813-19816. doi: 10.1039/d3ra01615c. PMID: 37404315; PMCID: PMC10316351.

 

Contact Us

Email: Kavindra.Nath@pennmedicine.upenn.edu
Phone: 215-746-7386
Fax: 215-573-2113
 
 

 

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