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Penn Image-Guided Interventions Laboratory (PIGI)

PIGI Penn Image Guided Intervention Laboratory Research Graphic

Focus

The interests of our laboratory center on translational research for the development of novel imaging approaches and advanced therapeutics in interventional oncology. Emphasizing a team science approach focusing on the convergence of image-guided interventions, cancer biology and molecular imaging, our research applies the study of fundamental cancer biology to inform the development of functional theranostic molecular imaging strategies. Current research focuses on integrated genomic profiling and genome editing to identify targetable vulnerabilities in hepatocellular carcinoma (HCC) that can be detected using dynamic nuclear polarization MR imaging (DNP-MRI).

 

Faculty and Staff

Terence P. Gade, MD, PHD

Terence P. Gade, MD, PHD

  • Co-Director, Penn Image-Guided Interventions (PIGI) Laboratory
  • Assistant Professor of Radiology
  • Assistant Professor of Cancer Biology

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Stephen J. Hunt, MD, PhD, DABR

Stephen J. Hunt, MD, PhD, DABR

  • Co-Director, Penn Image-Guided Interventions (PIGI) Laboratory
  • Assistant Professor of Radiology at the Hospital of the University of Pennsylvania

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Gregory J. Nadolski, MD

Gregory J. Nadolski, MD

  • Co-Director, Penn Image-Guided Interventions (PIGI) Laboratory
  • Assistant Professor of Radiology at the Hospital of the University of Pennsylvania

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Head shot of Austin Pantel

Austin Ryan Pantel, MD

Assistant Professor of Radiology at the Hospital of the University of Pennsylvania

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Dan Ackerman, PhD

Staff Scientist

Omar Johnson, BS

Research Specialist

Mike Mercadante, BS

Research Specialist

Nick Perkons

MD/PhD Student

Recent Publications

1. Perkons NR, Kiefer RM, Noji MC, Pourfathi M, Ackerman D, Siddiqui S, Tischfield D, Profka E, Johnson O, Pickup S, Mancuso A, Pantel A, Denburg MR, Nadolski GJ, Hunt SJ, Furth EE, Kadlecek S, Gade TPF. Metabolic Imaging Detects Latent Hepatocellular Carcinoma Domains Surviving Locoregional Therapy. 
Hepatology. 2019 Sep 25. doi: 10.1002/hep.30970.

2. D'Souza JC, Sultan LR, Hunt SJ, Gade TP, Karmacharya MB, Schultz SM, Brice AK, Wood AKW, Sehgal CM. Microbubble-enhanced ultrasound for the antivascular treatment and monitoring of hepatocellular carcinoma. Nanotheranostics. 2019 Oct 1;3(4):331-341. doi: 10.7150/ntno.39514. eCollection 2019.

3. Tischfield DJ, Ackerman D, Noji M, Chen JX, Johnson O, Perkons NR, Nadolski GJ, Hunt SJ, Soulen MC, Furth EE, Gade TP. Establishment of hepatocellular carcinoma patient-derived xenografts from image-guided percutaneous biopsies. Sci Rep. 2019 Jul 22;9(1):10546. doi: 10.1038/s41598-019-47104-9.

4. Shi D, Kiefer RM, Nishiofuku H, Cortes A, Nadolski GJ, Hunt SJ, Avritscher R, Gade TPF. Angiographic Atlas of the Visceral Vascular Anatomy in Translational Rat Models. J Vasc Interv Radiol. 2019 Dec;30(12):2009-2015.e1. doi: 10.1016/j.jvir.2019.03.005. Epub 2019 Jun 13.

5. D'Souza JC, Sultan LR, Hunt SJ, Schultz SM, Brice AK, Wood AKW, Sehgal CM. B-mode ultrasound for the assessment of hepatic fibrosis: a quantitative multiparametric analysis for a radiomics approach. Sci Rep. 2019 Jun 18;9(1):8708. doi: 10.1038/s41598-019-45043-z.

6. Perkons NR, Stein EJ, Nwaezeapu C, Wildenberg JC, Saleh K, Itkin-Ofer R, Ackerman D, Soulen MC, Hunt SJ, Nadolski GJ, Gade TP. Electrolytic ablation enables cancer cell targeting through pH modulation. Commun Biol. 2018 May 17;1:48. doi: 10.1038/s42003-018-0047-1. eCollection 2018.

Contact Us

University of Pennsylvania
421 Curie Blvd 
646 BRB II/III 
Philadelphia, PA 19104 

VA Medical Center 
3900 Woodland Avenue 
Research Building 
Philadelphia, PA 19104 

Phone: 215-573-9756
Email: lmakinen@upenn.edu

 

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