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Ciaran S. O’Brien, MD

Ciaran O'Brien
Medical School: Columbia University College of Physicians and Surgeons Undergraduate: St. John's College

About Dr. O'Brien

Ciaran is a vascular surgery fellow at the University of Pennsylvania with plans to pursue a career in academic vascular surgery focusing on comprehensive vascular care and resident education.

Prior to fellowship he completed general surgery residency at Penn. During residency he spent 2 years doing research in the lab of Dr. Matthew Levine on the influence of estrogen and HDAC inhibitors on ischemia reperfusion injury in mouse models of liver, kidney and extremity ischemia. 

Prior to residency he attended medical school at Columbia University College of Physicians and Surgeons, a post bacc program at Bryn Mawr College, and a BA in philosophy/comparative literature at St. John’s College in Annapolis, Maryland. 

Education

2016 - 2023
General Surgery Residency
University of Pennsylvania

2016
Columbia University College of Physicians and Surgeons

2010 - 2011
Bryn Mawr College, Bryn Mawr, Pennsylvania
Postbaccalaureate Premedical Program

2008
St. John's College, Annapolis, Maryland
Bachelor of Arts, Liberal Arts

Research 

2019 - 2021
Postdoctoral Research Fellow in the lab of Matthew Levine, MD/PhD and Wayne Hancock MBBS/PhD. Studying influence of histone deacetylase inhibitors and estrogen on ischemia reperfusion injury in murine models of liver, kidney and extremity ischemia.

2015 - 2016
Clinical outcomes research on Extracorporeal Mechanical Oxygenation with William Middlesworth, MD at the Children’s Hospital of New York
 
September 2011 - July 2012
New York Obesity Nutrition Research Center, St. Luke’s-Roosevelt, New York City
Studied hormonal changes as relates to diabetes remission after bariatric surgery under Blandine Laferrere, MD

Publications and Presentations

Original Papers

  1. Seth J Concors, Paul T Hernandez, Ciaran O'Brien, John DePaolo, Douglas R Murken, David D Aufhauser, Zhonglin Wang, Yan Xiong, Lauren Krumeich, Guanghui Ge, Ulf H Beier, Tricia R Bhatti, Alan P Kozikowski, Leandro A Alves Avelar, Thomas Kurz, Wayne W Hancock, Matthew H Levine. Differential Effects of HDAC6 Inhibition Versus Knockout During Hepatic Ischemia-reperfusion Injury Highlight Importance of HDAC6 C-terminal Zinc-finger Ubiquitin-binding Domain. Transplantation. 2024 Apr 30. doi: 10.1097
  2. Hernandez P, O’Brien C, Concors S, Wang Z, Ge G, Hancock W, Levine M. The Selective Estrogen Receptor Modulator, Raloxifene, Is Protective Against Renal Ischemia Reperfusion Injury. Transplantation. 2022 Nov 1;106(11):2166-2171
  3. Aufhauser DD Jr, Hernandez P, Concors SJ, O'Brien C, Wang Z, Murken DR, Samanta A, Beier UH, Krumeich L, Bhatti TR, Wang Y, Ge G, Wang L, Cheraghlou S, Wagner FF, Holson EB, Kalin JH, Cole PA, Hancock WW, Levine MH. HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury. Sci Rep. 2021 Apr 27;11(1):9018.
  4. O’Brien, C., Monteagudo, J., Schad, C., Cheung, E., & Middlesworth, W. (2017). Centrifugal pumps and hemolysis in pediatric extracorporeal membrane oxygenation (ECMO) patients: An analysis of Extracorporeal Life Support Organization (ELSO) registry data. Journal of Pediatric Surgery, 52(6), 975–978. https://doi.org/10.1016/j.jpedsurg.2017.03.022
  5. Dutia R, Embrey M, O’Brien CS, et al. Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes. Int J Obes (Lond). 2015;39(5):806–13. doi:10.1038/ijo.2015.1.
  6. O’Brien CS, Wang G, McGinty J, et al. Effects of gastrogastric fistula repair on weight loss and gut hormone levels. Obes Surg. 2013;23(8):1294–301. doi:10.1007/s11695-013-0917- z.

Presentations

  1. O’Brien C, Glaser J. Aorto-BiFemoral Bypass with Inferior Mesenteric Artery Re-Implantation for Chronic Mesenteric Ischemia. Presented at the Delaware Valley Vascular Society
    46th Annual Meeting, Thursday, May 19, 2024 The Union League of Philadelphia
  2. O’Brien C, Loh S. Reverse Extra Anatomic Arch Debranching and Thoracic Branched Endograft for Contained Rupture of Previous Type A Repair Complicated by Continued False Lumen Perfusion Requiring False Lumen Occlusion with Knickerbocker and Embolization Techniques Oral Presentation at International Aortic Summit, October 19th 2023, Noord, Aruba
  3. O’Brien C, Eddinger K, Loh S. Trans-graft Embolization of a Type II Endoleak Following EVAR Utilizing an RF Energy Wire Poster presentation at Eastern Vascular Society Annual Meeting, September 8th, 2023. Washington, DC
  4. Ciaran O’Brien MD, Jon Quatromoni MD, Robert Roses MD, Major K. Lee MD, Oksana Jackson MD, Benjamin Jackson MD. Shunting for Portal Vein Reconstruction. Presented at VAST3, August 6th 2022, Saratoga Springs, NY
  5. O’Brien C, Hernandez P, Concors S, Wang Z, Ge G, Bhatti T, Kozikowski A, Hancock WW, Levine MH. Hdac6 Inhibition Mediated Protection From Hepatic Ischemia Reperfusion Is Associated With Preserved Glutathione Levels. Poster Presentation at American Transplant Congress (ATC) June 4th, 2022, Boston MA
  6. O’Brien C, Hernandez P, Wang Z, Ge G, Hancock WW, Levine MH. Estrogen Receptor Beta Deletion is Protective in Renal Ischemia Reperfusion Injury in a Renal Specific Manner Accepted for Oral Presentation at American Transplant Congress (ATC) 2021 Virtual Connect, June 2021
  7. O’Brien C, Hernandez P, Concors S, Wang Z, Ge G, Bhatti T, Kozikowski A, Hancock WW, Levine MH. Tubastatin-a Mediated Protection from Liver Injury is Preserved in a Lymphocyte Deficient Model. Accepted for Poster Presentation at American Transplant Congress (ATC) 2021 Virtual Connect, June 2021
  8. O’Brien C, Hernandez P, Wang Z, Ge G, Hancock WW, Levine MH. Estrogen Receptor Beta Mediates Renal Ischemia Reperfusion Injury in a Renal Vascular Specific Manner. Virtual Oral Presentation at 16th Annual Academic Surgical Congress, February 2021
  9. O’Brien C, Hernandez P, Wang Z, Ge G, Bhatti T, Kozikowski A, Hancock WW, Levine MH Tubastatin-A, an HDAC6-specific Inhibitor, Decreases Hepatocellular Injury Via a Non Lymphocyte Pathway. Virtual Poster at American Society of Transplant Surgeons Winter Symposium, January 2021
  10. O’Brien C, Hernandez P, Wang Z, Ge G, Hancock WW, Levine MH. The Protective Effect of Estrogen Receptor Beta Deletion on Renal Ischemia Reperfusion Injury is Negated by Concomitant Estrogen Receptor Alpha Deletion. Virtual Poster at American Society of Transplant Surgeons Winter Symposium, January 2021
  11. O’Brien C, Hernandez P, Concors S, Wang Z, Ge G, Bhatti T, Kozikowski A, Hancock WW, Levine MH Tubastatin-A Mediated Protection from Acetaminophen-Induced Liver Injury is Preserved in Lymphocyte and Macrophage Deficient Mice. Virtual Poster Presentation at the Virtual Clinical Congress of the American College of Surgeons, October 2020
  12. O’Brien C, Hernandez P, Concors S, Wang Z, Ge G, Bhatti T, Kozikowski A, Hancock WW, Levine MH Tubastatin-A, an HDAC6-specific Inhibitor, Exerts its Protective Effect in Acetaminophen-Mediated Liver Injury Via a Non Immune Mediated Pathway. Virtual Poster Presentation at AASLD’s The Liver Meeting Digital Experience, October 2020
  13. O’Brien C., Hernandez P, Concors S, Krumeich L, Wang Z, Ge G, Bhatti T, Kozikowski A, Hancock WW, Levine MH. In a Murine Model of Acetaminophen-Mediated Liver Injury, Tubastatin-A, an HDAC6-specific Inhibitor, Improves Survival and Decreases Hepatocellular Injury Virtual Oral Presentation presented at American Transplant Congress, May 2020
  14. O’Brien C., Hernandez P, Concors S, Krumeich L, Wang Z, Ge G, Bhatti T, Kozikowski A, Hancock WW, Levine MH Tubastatin-A, an HDAC6-specific Inhibitor, Exerts its Protective Effect in Acetaminophen-Mediated Liver Injury Via a Non Immune Mediated Pathway Oral Presentation at ASC, February 2020
  15. O’Brien C., Hernandez P, Concors S, Krumeich L, Wang Z, Ge G, Bhatti T, Kozikowski A, Hancock WW, Levine MH Tubastatin-A, an HDAC6-specific Inhibitor, is Protective in Acetaminophen-Mediated Liver Injury Poster presented at ASTS Winter Symposium, January 2020
  16. O’Brien C., Monteagudo J., Schad C., Cheung E., Middlesworth W., (2016) Centrifugal Pumps and Hemolysis in Pediatric Extra-Corporeal Membrane Oxygenation (ECMO) Patients: an Analysis of Extracorporeal Life Support Organization (ELSO) Registry Data. Presented at the Annual American Academy of Pediatrics, Section on Surgery. October 2016, San Francisco, CA.

Memberships

  • Eastern Vascular Society
  • Delaware Valley Vascular Society
  • PA Medical Society
  • Society for Vascular Surgery

Awards / Honors

2021
William Y. Inouye Resident Award, Hospital of the University of Pennsylvania

2020
Jon Fryer Resident Scientist Scholarship from the American Society of Transplant Surgeons

2016
AOA, Columbia University College of Physicians and Surgeons
Alfred M. Markowitz Endowment for Scholars, Columbia University College of Physicians and Surgeons

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