Dr. Damrauer’s research utilizes genomic, proteomic, and metabolomic approaches to characterize the biological pathways and cellular mechanisms that are most relevant in the etiology, progression, and treatment of heart and vascular disease. He is a clinically active vascular surgeon at the Corporal Michael J. Crescenz VA (CMCVA) who treats Veterans with vascular disease on a daily basis, and he capitalizes on this in his research program as he leverage the techniques of molecular and genetic epidemiology to understand basic pathophysiology.
Dr. Damrauer's research group is working with investigators at the CMCVA, the VA Palo Alto Healthcare System, the VA Boston Healthcare System, and the Atlanta VA Medical Center, to lead the effort to understand the genetic basis of complex cardio-metabolic traits in the VA Million Veteran Program. Specifically, they are using both discovery-based and hypothesis-driven approaches to understand the genetics of peripheral artery disease (PAD), abdominal aortic aneurysm (AAA), and venous thromboembolism (VTE). In addition, they have ongoing related cardio-metabolic and PAD genetics projects utilizing a number of other large population-based cohorts, including the UK Biobank, PennMedicine BioBank, and the Pakistan Risk of Myocardial Infarction Study.