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Adele S. Ricciardi, MD, PhD

Adele Ricciardi
Medical School: Yale School of Medicine Undergraduate: University of North Carolina, Chapel Hill

About Dr. Ricciardi

Adele Ricciardi is a categorical resident in general surgery. She graduated from the University of North Carolina at Chapel Hill in 2010 with a Bachelor of Science in chemistry and biology with highest honors. She received her MD cum laude and her PhD in Biomedical Engineering from Yale University. Her graduate school research established the feasibility of using fetal gene editing as a method to treat genetic diseases before birth. Her work demonstrated therapeutic efficacy of in utero gene editing in pre-clinical models of beta-thalassemia and cystic fibrosis. She plans to continue to pursue a career in academic surgery and is interested in pediatric and fetal surgery.

Education

2011 - 2018
PhD - Yale University, Biomedical Engineering

2011 - 2015
MS, MPhil  - Yale University, Biomedical Engineering

Societies

  • American Society for Gene and Cell Therapy
  • International Fetal Medicine and Surgical Society
  • American Society of Hematology
  • International Fetal Transplantation and Immunology Society
  • American College of Obstetricians and Gynecologists
  • American Medical Association
  • Phi Beta Kappa

Awards

2020
MD/PhD Thesis Prize, awarded to the graduating MD/PhD student with the most outstanding dissertation

2020
Cum Laude, Yale School of Medicine

2019
John Addison Porter Prize, Yale dissertation prize for the best work of scholarship in any field

2019
International Fetal Medicine and Surgery Society Vandenberghe-Storz Silver Award

2019
Cystic Fibrosis Foundation Honoree - New Haven’s Finest

2019
International Fetal Medicine and Surgery Society Travel Award

2018
International Fetal Medicine and Surgery Society Vandenberghe-Storz
Award for the most outstanding presentation by a young investigator

2018
North American Cystic Fibrosis Conference Top 5 Abstract by a Junior Investigator in Basic Science

2018
American Society of Gene and Cell Therapy Excellence in Research Award

2018
American Society of Gene and Cell Therapy Meritorious Abstract Travel Award

2018
International Fetal Medicine and Surgical Society Travel Award

2012
Yale Surgical Society Travel Award, Yale School of Medicine, Department of Surgery

2011
Irene F. Lee Award - Chancellor's Award for the most Outstanding Graduating Senior Woman

2011
H.V.P. Wilson Award for Excellence in Cellular and Molecular Biology

2011
Nominated to attend the 61st Nobel Laureate Meeting in Lindau, Germany by Oliver Smithes (Nobel Prize in Physiology or Medicine, 2008)

2010
Highest Honors in Biology, University of North Carolina at Chapel Hill

2010
Phi Beta Kappa

2010
Carolina Research Scholar Award

2010
Gamma Sigma Epsilon, National Honor Society for Chemistry

2009
Beckman Foundation Scholarship

Research

2012 - 2020
Graduate School Research, Yale University
In utero gene editing with peptide nucleic acid nanoparticles
Departments of Biomedical Engineering, Therapeutic Radiology, Genetics, Surgery and Pediatrics
Mentors: W. Mark Saltzman, PhD; Peter M. Glazer, MD, PhD; David H. Stitelman MD; Marie E. Egan, MD

2007 - 2011
Undergraduate Research, University of North Carolina at Chapel Hill
Identification of novel factors involved in histone metabolism
Department Biochemistry and Biophysics
Mentor: William Marzluff, PhD

2006
High School Research, State University of New York, Albany
Bioinformatic approaches to study post-transcriptional gene regulation
Department of Biomedical Sciences
Mentor: Scott Tenenbaum, PhD

Publications

  1. Economos, N.G., Oyaghire, S., Quijano, E., Ricciardi, A.S., Saltzman, W.M., Glazer, P.M.: Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair. Molecules, 25(3): 735, 2020.
  2. Farrelly, J.S., Bianchi, A.H., Ricciardi, A.S., Buzzelli, G., Ahle, S., Freedman-Weiss, M., Luks, V.L., Saltzman, W.M., Stitelman, D.S.: Intra-amniotic injection of alginate microparticles loaded with basic fibroblast growth factor results in partial soft tissue coverage of the spinal defect in a rat Myelomeningocele model. Journal of Pediatric Surgery. 54(1): 80-85, 2019.
  3. Ricciardi, A.S., Bahal, R., Farrelly, J.S., Quijano, E., Bianchi, A.H., Luks, V.L., Putman, R., Lopez-Giraldez, F., Coskun, S., Song, E., Liu, Y., Hsieh, W-C., Ly, D.H., Stitelman, D.H., Glazer, P.M., Saltzman, W.M.: In utero nanoparticle delivery for site-specific genome editing. Nature Communications. 9: 2481, 2018. *Among the top 50 read articles in life and biologic sciences in Nature Communications in 2018.
  4. Ricciardi, A.S., Quijano, E., Putman, R., Saltzman, W.M., Glazer, P.M.: Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing. Molecules, 23(3): 632, 2018.
  5. Quijano, E., Bahal, R., Ricciardi, A.S., Saltzman, W.M., Glazer, P.M.: Therapeutic Peptide Nucleic Acids: Principles, Limitations, and Opportunities. Yale Journal of Biology and Medicine. 90: 583-589, 2017.
  6. Bahal, R., McNeer, N.A., Quijano, E., Liu, Y., Sulkowski, P., Turchick, A., Lu, Y.C., Bhunia, D., Mana, A., Greiner, D.L., Brehm, M., Cheng, C.J., Lopez-Giraldez, F., Ricciardi, A., Beloor, J., Krause, D.S., Kumar, P., Gallagher, P.G., Braddock, D.T., Saltzman, W.M., Ly, D.H., Glazer, P.M.: In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery. Nature Communications. 7: 13304, 2016.
  7. van Dams, R., Park, H., Alomari, A., Ricciardi, A., Rao, H., McNamara, J., DiLuna, M., Bindra, R.: Adjuvant hypofractionated partial-brain radiation therapy for pediatric Ewing sarcoma brain metastases: a case report and literature review. Journal of Neurosurgery: Pediatrics. 17(4): 434-438, 2015.
  8. Allakhverdieva, E.A., Grant, R.A., Quon, J.L., Ricciardi, A.S., DiLuna, M.L.: Extradural Decompression for the Treatment of Oculomotor and Oropharyngeal Symptoms in Chiari I Malformation: A Case Report. Brain Disord Ther, 4(2): 1-6, 2015.
  9. Ricciardi, A.: The Molecules of Life: Physical and Chemical Properties.  Yale Journal of Biology and Medicine, 88(1): 101-102, 2015.
  10. Ricciardi, A.: Thieme Atlas of Anatomy: General Anatomy and Musculoskeletal System. Yale Journal of Biology and Medicine. 88(1): 100.
  11. Ricciardi, A.S., McNeer, N.A., Anandalingam, K.K., Saltzman, W.M., Glazer, P.M.: Targeted Genome Modification via Triple Helix Formation. Cancer Genomics and Proteomics, 1176: 89-106, 2014.
  12. Lyons, S.M., Ricciardi, A.S., Guo, A.Y., Kambach, C., Marzluff, W.F.: The C-terminal extension of Lsm4 interacts directly with the 3’ end of the histone mRNP and is required for efficient histone mRNA degradation. RNA. 20(1): 88-102, 2014.
  13. von Moeller, H., Lerner, R.L., Ricciardi, A.S., Basquin, C., Marzluff, W.F., Conti, E.: Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins. Nucleic Acids Research. 41(16): 7960-7971, 2013.
  14. Doyle, F., Zaleski, C., George, A.D., Stenson, E.K., Ricciardi, A., Tenenbaum, S.A.: Bioinformatic tools for studying post-transcriptional gene regulation: The UAlbany TUTR collection and other informatic resources. Methods Mol Biol. 419:39-52, 2008

Invited Lectures

  1. Ricciardi A. Fetal Gene Editing. Robert J. Touloukian, M.D. Visiting Professorship in Pediatric Surgery, Yale School of Medicine Department of Surgery; New Haven, CT; March 2017.
  2. Ricciardi A. In utero gene editing. Educational rounds for the sections of Maternal Fetal Medicine and Neonatology, Yale New Haven Hospital; New Haven, CT; May 2017.
  3. Ricciardi A. In Utero Nanoparticle Delivery for Site-Specific Genome Editing. North American Cystic Fibrosis Conference; Indianapolis, IN; November 2017.
  4. Ricciardi A. Fetal Gene Editing. Robert J. Touloukian, M.D. Visiting Professorship in Pediatric Surgery, Yale School of Medicine Department of Surgery; New Haven, CT; March 2018.
  5. Ricciardi A. The ethics of fetal gene editing. Responsible Conduct of Research Course in the Department of Biomedical Engineering; New Haven, CT; April 2018.
  6. Ricciardi A. The very happy middle of cystic fibrosis. TruCode Gene Repair — All Hands Research Meeting; San Francisco, CA; September, 2018.
  7. Ricciardi A. In utero gene editing as a treatment for β-thalassemia. Red Cell Club Meeting; New Haven CT; October 2018.
  8. Ricciardi A. In utero gene editing as a treatment for beta-thalassemia. Seminar for the PENN-CHOP Blood Center for Patient Care and Discovery; Philadelphia, PA; January 2019.
  9. Ricciardi A. and Stitelman D. Discussing research ethics with your mentor. Responsible Conduct of Research Course in the Department of Biomedical Engineering; New Haven, CT; April 2019.
  10. Ricciardi A. and Peter M. Glazer. In vivo correction of beta-thalassemia in hematopoietic stem cells by infusion of PNA-nanoparticles. Fanconi Anemia Research Fund, Gene Therapy for Fanconi Anemia 2019: Challenges and Opportunities; San Francisco, CA; April 2019.
  11. Ricciardi A. Nanoparticle delivery for in utero gene editing. Saltzman Celebration and Symposium; New Haven, CT; September 2019.
  12. Ricciardi A. and Stitelman D. Research Ethics. Responsible Conduct of Research Course in the Department of Biomedical Engineering; New Haven, CT; April 2020.
  13. Ricciardi A. In utero nanoparticle delivery. Drug Formulation and Delivery Course in the Department of Chemical Engineering, The Cooper Union, online during COVID-19, May 2020.

Oral Presentations

  1. Ricciardi A, Barone C, Putman R, Quijano E, Gupta A, Nguyen R, Freedman-Weiss M, Ullrich S, Piotrowski-Daspit A, Stitelman DH, Saltzman WM, Glazer PM, Egan ME. Systemic fetal gene editing as a treatment for cystic fibrosis.Yale Pediatric Research Forum; New Haven, CT; May 2020.
  2. Ricciardi A, Barone C, Putman R, Quijano E, Gupta A, Farrelly J, Luks V, Nguyen R, Saltzman WM, Glazer PM, Egan ME, Stitelman DH. Systemic fetal gene editing as a treatment for cystic fibrosis. International Fetal Medicine and Surgical Society 38th Annual Meeting; Sils, Switzerland; October 2019.
  3. Piotrowski-Daspit AS, Barone C, Kauffman AC, Lin CY, Nguyen N, Ricciardi AS, Gupta A, Glazer PM, Saltzman WM, Egan ME. Gene editing of the F508del cystic fibrosis mutation ex vivo and in vivo by PNA nanoparticles. The 33rd Annual North American Cystic Fibrosis Conference; Nashville, TN; October 2019.
  4. Ricciardi A, Barone C, Putman R, Quijano E, Gupta A, Farrelly J, Luks V, Nguyen R, Saltzman WM, Glazer PM, Egan ME, Stitelman DH. Systemic fetal gene editing as a treatment for cystic fibrosis. American Pediatric Surgical Association Annual Meeting - 50th Anniversary; Boston, MA; May 2019.
  5. Ricciardi AS, Barone C, Putman R, Quijano E, Gupta A, Nguyen R, Mandl M, Lopez-Giraldez F, Freedman-Weiss M, Stitelman DH, Glazer PM, Saltzman WM, Egan ME. Systemic in utero gene editing as a treatment for cystic fibrosis. 22nd Annual Meeting of the American Society for Gene and Cell Therapy; Washington, DC; April 2019.
  6. Ricciardi A, Barone C, Putman R, Quijano E, Gupta A, Luks VL, Farrelly JS, Nguyen R, Mandl H, Stitelman D, Glazer PM, Saltzman WM, Egan ME. In utero gene editing as a treatment for cystic fibrosis. The 32nd Annual North American Cystic Fibrosis Conference; Denver, CO; October 2018.
  7. Barone C, Jamali H, Gupta A, Ricciardi A, Quijano E, Piotrowski-Daspit A, Saltzman WM, Glazer PM, Egan ME. Correction of CFTR mutations using peptide nucleic acids delivered in polymeric nanoparticles in vitro. The 32nd Annual North American Cystic Fibrosis Conference; Denver, CO; October 2018.
  8. Ahle S, Spindler S, Freedman-Weiss M, Ricciardi A, Luks V, Piotrowski-Daspit A, Goodfriend A, Mandl H, Tietjen G, Saltzman WM, Stitelman DH. Nanoparticle Size and Composition Influences the Distribution of Nanoparticles to the Fetal Mouse Lung. American Academy of Pediatrics National Conference & Exhibition; Orlando, FL; November 2018.
  9. Ricciardi A, Bahal R, Farrelly J, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh W-C, Ly DH, Stitelman DH, Glazer PM, Saltzman WM. In Utero Gene Correction Mediated by PNA-Nanoparticles; International Fetal Medicine and Surgical Society 37th Annual Meeting; Bali, Indonesia; August 2018.
  10. Ricciardi A, Bahal R, Farrelly J, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh W-C, Ly DH, Stitelman DH, Glazer PM, Saltzman WM. In Utero Gene Correction Mediated by PNA-Nanoparticles; American Society of Gene and Cell Therapy Annual Meeting; Chicago, IL; May 2018.
  11. Farrelly J, Bianchi A, Ricciardi A, Buzzelli G, Ahle S, Luks V, Saltzman WM, and Stitelman DH. Intra-amniotic Injection with Microparticles Loaded with Fibroblast Growth Factor Causes Partial Spinal Cord Coverage in Rat Myelomeningocele; International Fetal Medicine and Surgical Society 36th Annual Meeting; Jackson Hole, WY; October 2017.
  12. Ricciardi A, Stitelman D, Glazer PM, and Saltzman WM. Nanoparticles for Site-Specific Gene Editing In Utero. Yale Pediatric Research Forum; New Haven, CT; May 2017.
  13. Ricciardi A, Matouk C, and DiLuna M. Utility of Vessel Wall MR Imaging in Pediatric Neurovascular Disease. 43rd Annual Meeting of the International Society for Pediatric Neurosurgery; Izmir, Turkey; October 2015.
  14. Ricciardi A, Matouk C, and DiLuna M. Utility of Vessel Wall MR Imaging in Pediatric Neurovascular Disease. Neurosurgical Society of America 68th Annual Meeting; Newport Beach, CA; April 2015.
  15. Quon J, Ricciardi A, Grant R, DiLuna M. Motion Sparing Arthrodesis for Symptomatic Spondylolysis in Children: Results and Technical Considerations. Talk accepted for the 42nd Annual Meeting of the International Society for Pediatric Neurosurgery; Rio de Janiero, Brazil; November 2014.
  16. Quon J, Grant R, Ricciardi A, DiLuna M. Single-Stage Multilevel Posterior Extracavitary Corpectomy and Fusion for Spinal Reconstruction in Children: Results, Technical Considerations and Limitations. Talk accepted for the 42nd Annual Meeting of the International Society for Pediatric Neurosurgery; Rio de Janiero, Brazil; November 2014.
  17. Quon J, Ricciardi A, DiLuna M. Chiari decompression for children with syrinx: extradural. 67th Annual Meeting of the Neurosurgical Society of America; St. Andrew-by-the-Sea, New Brunswick, Canada; June 2014.
  18. Ricciardi A, Grant R, Didiano R, DiLuna M. Motion Sparing Arthrodesis for Symptomatic Spondylolysis in Children: Results and Technical Considerations. 7th Annual Meeting of the American Society of Pediatric Neurosurgeons; Costa Rica; January 2014.
  19. Ricciardi A, Lerner R, Lyons S, Duronio R, Marzluff W. Identification of Novel Factors Involved in Histone mRNA Metabolism. Fall 2010 Undergraduate Research Symposium; Chapel Hill, NC; November 2010.
  20. Ricciardi A, Lerner R, Marzluff W. Factors Involved in Histone mRNA Translation. Atlantic Coast Conference Meeting of the Minds; Raleigh, NC; April 2008.

Poster Presentations

  1. Putman R, Ricciardi AS, Glazer PM, Saltzman WM. Synthetic nanoparticle delivery to mouse embryos for site-specific gene editing. American Society for Gene and Cell Therapy 23rd Annual Meeting; Online due to COVID-19; May 2020.
  2. Piotrowski-Daspit AS, Barone C, Kauffman AC, Lin CY, Nguyen R, Ricciardi AS, Gupta A, Glazer PM, Saltzman WM, Egan ME. Gene editing of the F508del cystic fibrosis mutation ex vivo and in vivo mediated by PNA nanoparticles. The 33rd Annual North American Cystic Fibrosis Conference; Nashville, TN; October 2019.
  3. Piotrowski-Daspit AS, Barone C, Lin CY, Jamali H, Nguyen R, Ricciardi AS, Gupta A, Glazer PM, Saltzman WM, Egan ME. Gene correction of class I CFTR mutations mediated by PNA nanoparticles. The 33rd Annual North American Cystic Fibrosis Conference; Nashville, TN; October 2019.
  4. Quijano, E, Bahal R, Liu Y, Ricciardi AS, Mandl H, Suh HW, Lezon-Geyda, K, Gallagher PG, Saltzman WM, Glazer PM. Nanoparticle-mediated correction of the sickle cell mutation. American Society of Gene and Cell Therapy 22nd Annual Meeting; Washington, DC; April 2019.
  5. Ricciardi AS, Barone C, Putman R, Quijano E, Gupta A, Nguyen R, Mandl H, Lopez-Giraldez F, Freedman-Weiss M, Glazer PM, Saltzman WM, Egan ME, Stitelman DH. Systemic in utero gene editing as a treatment for cystic fibrosis. Annual Yale Surgery Research Day; New Haven, CT; April 2019.
  6. Ricciardi A, Barone C, Putman R, Quijano E, Gupta A, Luks VL, Farrelly JS, Nguyen R, Mandl H, Stitelman D, Glazer PM, Saltzman WM, Egan ME. In utero gene editing as a treatment for cystic fibrosis. The 32nd Annual North American Cystic Fibrosis Conference; Denver, CO; October 2018.
  7. Barone C, Jamali H, Gupta A, Ricciardi A, Quijano E, Piotrowski-Daspit A, Saltzman WM, Glazer PM, Egan ME. Correction of CFTR mutations using peptide nucleic acids delivered in polymeric nanoparticles in vitro. The 32nd Annual North American Cystic Fibrosis Conference; Denver, CO; October 2018.
  8. Farrelly JS, Bianchi AH, Ricciardi AS, Buzzelli G, Ahle S, Freedman-Weiss M, Luks VL, Saltzman WM, Stitelman DS. Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of Myelomeningocele. New England Surgical Society 99th Annual Meeting; Portland, ME; September 2018.
  9. Ahle S, Spindler S, Freedman-Weiss M, Ricciardi A, Luks V, Piotrowski-Daspit A, Goodfriend A, Mandl H, Tietjen G, Saltzman WM, Stitelman DH. Nanoparticle Delivery to Fetal Mouse Lungs for Therapeutic Nucleotide Delivery. American Academy of Pediatrics National Conference and Exhibition; Orlando, FL; November 2018.
  10. Luks V, Ricciardi AS, Tietgen GT, Farrelly J, Ahle S, Saltzman WM, Egan ME, Stitelman DH. Cell-Specific Targeting Enhances Intracellular Uptake of Nanoparticles in Cystic Fibrosis Bronchial Epithelial Cells. The 31st Annual North American Cystic Fibrosis Conference; Indianapolis, IN; November 2017.
  11. Ahle S, Farrelly J, Ricciardi A, Luks V, Saltzman WM, and Stitelman DH. Characterizing the Biodistribution of Intravenously and Intra-amniotically Injected Nanoparticles in Rat Fetuses. New England Surgical Society 98th Annual Meeting; Bretton Woods, NH; September 2017.
  12. Ricciardi A, Bahal R, Bianchi A, Farrelly J, Luks V, McNeer N, Quijano E, Stitelman D, Glazer P, Saltzman WM. Nanoparticles for site-specific genome editing in utero. Yale School of Medicine Student Research Day; New Haven, CT; May 2017.
  13. Farrelly J, Bianchi A, Ricciardi A, Ahle S, Luks V, Saltzman WM and Stitelman DH. Intra-Amniotic Delivery of Biodegradable Microparticles and Nanoparticles to the Spinal Defect in a Rat Myelomeningocele Model. American Society of Gene & Cell Therapy; Washington, DC; May 2017.
  14. Ricciardi A, Bahal R, Bianchi A, Farrelly J, Luks V, McNeer N, Quijano E, Stitelman D, Glazer P, Saltzman WM. Nanoparticles for site-specific genome editing in utero. Yale School of Medicine Student Research Day; New Haven, CT; May 2016.
  15. Ricciardi A, Quon J, Grant R, Al-Omari A, Kelley B, Vortmeyer A, DiLuna M. Evidence of a Continuum from Rathke Cleft Cyst to Craniopharyngioma. Poster accepted for the 42nd Annual Meeting of the International Society for Pediatric Neurosurgery; Rio de Janiero, Brazil; November 2014.
  16. Ricciardi A, Lerner R, Lyons S, Duronio R, Marzluff W. Identification of Novel Factors Involved in Histone mRNA Metabolism. 5th Annual Atlantic Coast Chromatin Conference; Chapel Hill, NC; October 2010.
  17. Ricciardi A, Lerner R, Lyons S, Duronio R, Marzluff W. Identification of Novel Factors Involved in Histone mRNA Metabolism. 2010 Twelfth Annual Beckman Scholar Symposium; The Beckman Institute; Irvine, CA; July 2010.
  18. Ricciardi A, Lerner R, Lyons S, Duronio R, Marzluff W. Characterization of c-Myc Interaction with SLIP1, a Factor Involved in Histone mRNA Translation. Symposium on RNA Biology VIII: RNA Tool and Target; Research Triangle Park, NC; October 2009.
  19. Ricciardi A, Lerner R, Lyons S, Duronio R, Marzluff W. Identification of SLIP1 Binding Proteins. Protein Synthesis and Translational Control Meeting; European Molecular Biology Laboratories Heidelberg, Germany; September 2009.
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