Penn Evidence-Based Literature Review (PEBLR)

Summarized highlights from contemporary literature in surgical and allied disciplines for general surgery residents.

Cardiothoracic Surgery

Central venoarterial extracorporeal membrane oxygenation as a bridge to recovery after pulmonary endarterectomy in patients with decompensated right heart failure (PubMed)
bdelnour-Berchtold E, Donahoe L, McRae K. et al. J Heart Lung Transplant. 2022 Jun;41(6):773-779.
Contributor: Mallory Hunt

Brief Synopsis

This retrospective cohort study across two time periods found that using central extracorporeal membrane oxygenation (ECMO) as a bridge to recovery after pulmonary endarterectomy (PEA) is beneficial in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and associated decompensated right heart failure (DRHF) - namely resulted in a 26% drop in in-hospital mortality.

Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) can be treated with pulmonary endarterectomy (PEA), a procedure which has excellent early and long-term outcomes. However, CTEPH patients with distal disease and decompensated right heart failure (DRHF) are at high risk of postoperative hemodynamic compromise and are thus particularly challenging to treat. Extracorporeal membrane oxygenation (ECMO) has been used successfully to bridge lung transplant patients with right ventricular compromise to recovery post-operatively. This article examines the use of post-operative central ECMO has a bridge to recovery in CTEPH patients with DRHF.

This is a retrospective cohort study of all patients undergoing PEA at the Toronto General Hospital between January 2005 and December 2019 (n=388). Patients were divided into two groups: those with DHRF before PEA (n=40) and those without (n=348). DRHF was defined as patients who presented with symptoms of low cardiac output in the presence of RV dysfunction and secondary end organ malperfusion. All PEA cases were performed using a standard sternotomy approach with deep hypothermic circulatory arrest (DHCA) at 20°C. Two analysis periods were defined: before and after 2013, when central VA ECMO as bridge to recovery was implemented. The decision to place a patient on central VA ECMO was made intraoperatively upon failure to wean from bypass in the presence of (i) hemodynamic compromise despite pressors and/or inotropes, (ii) isosystemic pulmonary pressures, (iii) severe hypoxemia, or (iv) hemoptysis. Primary endpoints included demographic, hemodynamic, and long-term outcome parameters.

Among 388 patients undergoing PEA in the study period, 40 (10.3%) had a recorded admission for DRHF prior to PEA. Characteristics of the DRHF group did not vary between the two time periods analyzed. DRHF patients were more likely to have been started on medical pulmonary hypertension (PH)-targeted therapy pre-operatively. While DHCA and cross clamp times did not differ between the DRHF and elective groups, the DRHF group had significantly longer bypass times, reflecting the degree of hemodynamic compromise observed intraoperatively in these patients.

In-hospital mortality for the entire cohort was 3.1% and stable across the observed time periods. However, DRHF patients had a significantly higher mortality rate compared to the elective group (15% vs 2%). The use of central VA ECMO was associated with a significant decrease in mortality rate in the DRHF group, from 31% in 2005-2013 to 4% in 2014-2019. Slightly over 1/3 (38%) of DRHF patients required ECMO in the latter time period. The majority were transitioned to central ECMO intraoperatively due to persistent pulmonary hypertension after PEA with hemodynamic compromise. In addition to an in-hospital mortality benefit, long-term outcomes were also excellent: with 5-year survival rates of 84% (DRHF patients) and 90% (elective group).

Take Home Points:

  • Patients with chronic thromboembolic pulmonary hypertension (CTEPH) and associated decompensated right heart failure (DRHF) pose a unique challenge to surgeons due to high risk of postoperative hemodynamic compromise.
  • Postoperative extracorporeal membrane oxygenation (ECMO) can be useful as a bridge to recovery in CTEPH patients with DRHF and is associated with improved in-hospital mortality and excellent long-term outcomes.
  • This study is limited by a single center observational experience, and larger studies are necessary to generalize the above findings. However, despite this, the experience described here provides a promising therapy for a challenging, complicated patient population.

Endocrine Surgery

Title Complication Rates of Total Thyroidectomy vs Hemithyroidectomy for Treatment of Papillary Thyroid Microcarcinoma: A Systematic Review and Meta-analysis (PubMed)
Hsiao V, Light TJ, Adil AA, Tao M. et al. JAMA Otolaryngol Head Neck Surg. 2022 May 5:e220621.
Contributor: Amanda Bader

Brief Synopsis

In this systematic review and meta-analysis, hemithyroidectomy as the treatment for papillary thyroid microcarcinoma was found to have lower complication rates but higher cancer recurrence as compared to total thyroidectomy.

Summary: Papillary thyroid microcarcinomas (PTMCs), defined as papillary thyroid cancer measuring less than or equal to 1.0 cm in diameter, have increased in incidence over the past several years. Historically, total thyroidectomy has been the gold standard treatment option for PTMC; however, more recently, hemithyroidectomy with close surveillance has become an acceptable alternative for low risk differentiated cancers. Previous studies have shown hemithyroidectomy to be associated with a lower surgical risk profile, lower cost and decreased hospital stay compared to total thyroidectomy; plus, it obviates the need for lifelong postoperative thyroid hormone replacement in most cases.

The goal of this study was to perform a systematic review and meta-analysis to compare complications rates after total thyroidectomy versus hemithyroidectomy for PTMC. Several literature search engines were used to find original articles that reported both outcomes and at least one complication of interest in PTMC treatment and the effects of these articles were pooled. The main outcomes and complications of interest included cancer recurrence and site, mortality, vocal fold paralysis, hypoparathyroidism, and hemorrhage/hematoma.

Ultimately, 17 studies met inclusion criteria and were analyzed; this included 1416 patients undergoing hemithyroidectomy (HT) and 2411 patients undergoing total thyroidectomy (TT).

They found that:

  • HT (as compared to TT) was associated with lower risk of temporary vocal fold paralysis (3.3% vs 4.5%, RR 0.4, 95% CI 0.2-0.7), temporary hypoparathyroidism (2.2 vs 21.3%, RR 0.1, 95% CI 0.0 – 0.4) and permanent hypoparathyroidism (0% vs 1.8%, RR 0.2, 95% CI 0.0-0.8)
  • Overall recurrence rates were higher for HT than TT (3.8% vs 1.0%) (RR 2.6; 95% CI, 1.3-5.4). Contralateral lobe recurrence was associated with overall higher recurrence rates for HT than TT (2.3% vs 0%, weighted absolute risk difference, −16%). However, no recurrence rate difference was detected in the thyroid bed (0.3% vs 0.2%) (RR 0.8; 95% CI, 0.2-4.1) or neck (1.2% vs 0.8%) (RR 0.6; 95% CI, 0.2-1.5)
  • Interestingly, they also assess the risk of bias in these 17 studies and found to have low risk of bias (10/17 studies).

Overall, this work helped to characterize and quantify the risks and benefits of performing a HT for papillary thyroid microcarcinoma as compared to TT. Although HT was associated with lower complications rates, there remained the risk of cancer in the contralateral lobe. Moving forward, this work will aid in making treatment recommendations and patient counseling.

Surgical Education

Identification of Leadership Behaviors that Impact General Surgery Junior Residents' Well-being: A Needs Assessment in a Single Academic Center (PubMed)
Torres-Landa S, Moreno K, Brasel KJ. et al. J Surg Educ. 2022 Jan-Feb;79(1):86-93.
Contributor: Drew Goldberg, Alex Warshauer

Brief Synopsis

Leadership is a core competency required by the ACGME. This study links leadership behaviors from senior residents to significant short-term and long-term impact on junior resident well-being. Strong leaders positively impact individual growth, psychological safety, resident education, teamwork, and wellbeing. This highlights the need for leadership training programs and curricula in general surgery, especially those that that cultivate Transformational Leadership styles as opposed to Transactional Leadership alone.

Summary:

Background: Addressing well-being within surgery residency training has become a focus for the ACGME given high rates of burnout. Most interventions are focused on individual level skills and not ways in which residents can impact the well-being of those around them. There is a gap in research on the role that resident leadership has on co-resident and team well-being. Therefore, a needs assessment was conducted prior to establishing a leadership development program at one of the largest academic residency programs in the US (OHSU).

Study design: A semi-structured question script was administered to surgical residents by a research team that included 2 surgical faculty, a social scientist with education expertise, and a surgical research fellow. Residents were asked about traits of senior residents who were regarded as great leaders versus those seen as poor leaders, and about how they impacted the resident’s well-being, both positively and negatively. Six focus groups were created by the core research team divided by PGY level, all performed virtually for 60 minutes. Data analysis was performed using grounded theory and the focus groups were conducted until data saturation was reached. The transcripts were coded and analysis performed through the consensus amongst the core research team.

Results: A total of 30 (47%) surgical residents from the program participated in the focus group with 63% women and 37% men. Participants from each class participated: PGY1 (10), PGY2 (6), PGY3 (5), PGY4 (5) and PGY5 (4). Effective resident leaders were noted to emphasize similar behaviors including 1) being supporting and empowering; 2) focusing on team building by creating a common goal, psychological safety, camaraderie and caring for others; 3) showing proficient management skills by setting expectations, plans, delegating tasks and providing feedback; 4) having high levels of emotional intelligence; 5) effectively communicating through a clear message and actively listening to junior residents and 6) proactively engaging in teaching. The consequences of the above traits were promoting individual residents’ growth and was directly linked with residents well-being, allowing them to prioritize their own optimized mental state. Residents deemed poor leaders were found to be not supportive and did not empower fellow team members, seemed unapproachable and unwilling to help, did not advocate for junior residents, lacked communication skills and did not focus on creating a team environment, and lacked management skills and emotional intelligence. The consequences of a poor leader were creating an overwhelming amount of negative emotions, lack of psychological safety, poor team dynamics and broken workflows. Mixed leadership behaviors, described as effective in some ways but ineffective as others were perceived by some residents as effective and ineffective to others.

Discussion: Leadership today requires a more team-focused, holistic approach that aligns the group’s collective goals. Transformational Leadership (inspirational, create a common mission) as opposed to Transactional Leadership (task oriented, give and take) can improve team well-being, build psychological safety, and potentially impact team efficiency and patient safety. This study demonstrates some of the actions of effective and ineffective resident leaders and shows the impacts they can have on their teams. An important takeaway is the finding that different PGY levels have different needs from their leaders, requiring leaders to tailor their leadership style to each team member. The link between leadership and well-being argues for the need to develop leadership curricula in general surgery residency.

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