The subspecialty of Undersea and Hyperbaric Medicine deals with the therapeutic use of high environmental oxygen pressure and the prevention of injury and illness due to exposure to environments with elevated ambient pressure. The scope of the subspecialty emphasizes occupational, environmental, safety, and clinical aspects of diving, hyperbaric chamber operations and hyperbaric oxygen (HB02) therapy. At completion of the fellowship, the trainee will:

1. Develop a knowledge base and clinical skills necessary to:
   • Evaluate and prescribe appropriate HB02 therapy for all the medical conditions accepted by the Undersea and Hyperbaric Medical Society as amenable to treatment.
   • Manage patients during hyperbaric treatment.
   • Evaluate individuals for scuba diving activities, and treat diving-related illnesses.
2. Discuss investigational indications for the use of HB02 and areas for future research.
3. Develop requisite academic skills to be an effective teacher and researcher in diving and hyperbaric oxygen therapy.

Fellowship candidates must be graduates of an approved residency and hold or obtain a valid medical license for the state of Pennsylvania. The educational program is designed for two fellows per year. The core focus is participation in clinical and research activities of the Division of Undersea and Hyperbaric Medicine, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania.

1. Required clinical activities:
   • Participate in HBO2 clinical operations by monitoring daily treatment sessions and emergency on-call treatments.
   • Provide consultation service to physicians referring patients
   • Participate in weekly clinics including wound care, vascular surgery, plastic surgery, and diving medicine.
2. Didactic curriculum and HBO2 core lecture series:
   • Weekly clinical rounds discussion.
   • Weekly Grand Rounds.
   • Bi- weekly hyperbaric medicine lecture series including formal lectures, literature review, and Undersea and Hyperbaric Medicine text reviews.
3. Development of four lectures for demonstration of knowledge in core curriculum subjects. These will be presented at community hospitals, rotating resident lectures, in-house grand rounds, and inter-fellowship web conferences.
4. Required participation in one or more on-going research project. Based on a fellow’s prior training and interests, a new project may be developed and funded by internal resources.
5. Elective clinical opportunities.

1. History of pressure therapy in medicine
2. Physiologic effects of hyperbaric oxygen
   • Increase in healing of hypoxic wounds
   • Inhibition of Clostridial alpha toxin
   • Lessening carbon monoxide toxicity
   • Influence on various blood cells
   • Vasoconstriction
   • Decrease in edema in burns and post-ischemic tissue
   • Preservation of tissue flaps
   • Decrease in lipid peroxidation
   • Inhibit PMN adherence/role of HBO2 in ischemia reperfusion injuries
3. Mechanical effects of pressure
   • Reduce bubble volume
   • Inert gases, supersaturation, re-dissolving nitrogen bubble
4. Oxygen toxicity
5. Multiplace chamber operation
   • Equipment considerations
   • Patient considerations
   • Emergency procedures
6. Monoplace chamber operation
   • Equipment considerations
   • Patient considerations
   • Emergency procedures
7. Approved indications for hyperbaric oxygen therapy
   • Air or gas embolism
   • Carbon monoxide poisoning
   • Carbon monoxide poisoning complicated by cyanide poisoning
   • Clostridial myonecrosis
   • Acute traumatic ischemia
   • Decompression sickness
   • Enhancement of healing in selected problem wounds
   • Exceptional blood loss
   • Necrotizing soft tissue infections
   • Refractory osteomyelitis
   • Radiation tissue damage
   • Compromised skin grafts and flaps
   • Thermal burns
8. Contraindications and side effects of HBO
   • Absolute
     1. Untreated pneumothorax
   • Relative
     1. COPD with CO2 retention, bullous disease
     2. Selected medications (e.g. bleomycin)
     3. Seizure disorder
     4. Recent thoracic surgery
     5. Ear or sinus surgery
     6. Cataracts
     7. Claustrophobia
     8. Concurrent chemotherapy and/or radiotherapy
     9. Optic neuritis
   • Side effects
     1. Barotrauma (otic, sinus, pulmonary)
     2. Visual refractive changes
     3. Oxygen induced seizures and other CNS effects
     4. Claustrophobia
     5. Pulmonary oxygen toxicity
9. Tissue oxygen measurements – Transcutaneous oximetry
10. Investigational areas (examples)
    • Ischemia reperfusion injury
    • Myocardial infarction
    • Cerebrovascular accident
11. Administrative aspects of chamber operation
    • Guidelines for hyperbaric facilities
    • Economic aspects
    • Quality assessment
    • Peer review
12. Care of the critically ill patient in a hyperbaric chamber
    • Drugs and critical care equipment under pressure
    • Nursing considerations
    • Resuscitation management
13. Hyperbaric medicine in pediatric practice
    • Indications for HBO in children
    • Special contraindications
    • Psychological preparation and support
14. Physiologic effect of pressure and immersion
    • Physics of diving
    • Hypothermia and hyperthermia
    • High pressure nervous syndrome
    • Breath-hold diving
15. Decompression Theory
    • Inert gas exchange
    • Mechanisms of bubble formation
    • Saturation decompression theory
    • Repetitive diving
    • Surface decompression
    • Bubble detection
    • Mixed gas diving
    • Altitude diving, flying after diving
16. Pathophysiology and treatment of decompression illnesses
    • Signs and symptoms of decompression sickness and AGE
    • Mechanisms of gas entry and distribution
    • Effects of bubbles
    • Dysbaric osteonecrosis
    • Barotrauma
    • Treatment of decompression illnesses
17. Health hazards in divers
    • Medical examination and standards for hyperbaric exposure: Military, commercial, recreational, scientific, hyperbaric personnel
    • Recognition and treatment of hazardous marine life injuries